Jinze Wu
My research project is simulating the layered honeycomb material BaCo2(AsO4)2 at low temperature and high applied in-plane magnetic field, since BaCo2(AsO4)2 is theorized by the Kitaev honeycomb model to exhibit Kitaev Quantum Spin Liquid (KQSL) behaviors. Currently, the Kitaev honeycomb model is still a very new theory to explain the quantum spin liquid states, and any simulations that corroborate or contradict the experimental results will be examined within the theoretical framework of this model in order to identify possible inconsistencies between the model and the experimental results. This topic will […]
Angela Sun
Lung cancer is a leading cause of cancer-related death, even in those who have never smoked cigarettes. In the United States, about 10–15 percent of lung cancers arise in never-smokers, and approximately 17,000 to 26,000 never-smokers die annually from the disease. Despite this fact, knowledge about the epidemiology of lung cancer in never-smokers remains limited. Our proposed study will be the first to elucidate the incidence rates of lung cancer in never-smokers in our integrated health system, specifically addressing differences by sex and race that are not well established in […]
Joshua Wong
My project will investigate how mating status (virgin or mated females) affects how Drosophila, commonly known as fruit flies, will intake bitter substances when mixed in solutions with sugar. Because mated females have been shown to intake more nutrients like sugars or amino acids for the purpose of egg production, I want to investigate if mated females will also tolerate more intake of bitter (aversive) compounds that are mixed with sugars. This dynamic is super interesting because fruit flies have two different mechanisms to avoid aversive compounds: one activates bitter […]
Joanna Veres
Living on Earth, gravity constantly exerts a mechanical load on the spine, which puts pressure on the discs and causes them to gradually lose height throughout the day. However, this constant mechanical load is greatly reduced while in environments with microgravity such as on the international space station. Due to long-term mechanical unloading in the presence of microgravity, astronauts have an incidence of disc herniation 4.3 times that of the general population. Being able to better describe the physiological changes to the IVD caused by prolonged time spent in microgravity […]
Lillian Litvak
Our research aim is to provide greater insights into the functions of NLR immune receptors, which are part of the second tier of the plant immune system, based on our current knowledge of their protein structure and mechanism. As we work toward this goal, we will answer basic research questions about how these highly conserved immune receptors detect pathogens and signal an immune response. More specifically, what region of the receptor recognizes the pathogen effector? Does this region also play a role in switching the receptor to the activated […]
Alexander Kvitsinski
The benzylic methylene unit (Ar-CH2-R) is a common motif in drug candidates and pharmaceuticals. However, the propensity of its C-H bonds toward oxidation creates the challenge of metabolic stability. One solution is the substitution of this motif with the benzylic difluoromethylene or difluorobenzyl units (Ar-CF2-R), wherein the reactive C-H bonds are substituted with metabolically more stable C-F bonds. However, despite the potential advantage of such an approach, few pharmaceuticals containing this motif have been commercialized. This project focuses on the development of novel Ar-CF2-M synthons for C-C cross-coupling chemistry. First, […]
Sara Koupaei
I am interested in learning more about the unique rhamnolipid methyl esters (RMEs) produced by the pyrophilous bacterium Paraburkholderia sp. F3 and RMEs’ ecological significance. Previous endeavors in this project have uncovered the production of the unique RMEs by P. sp. F3, which first attracted attention due to its antibiotic activity against a pyrophilous fungus (Pyronema omphalodes) found in the same environment as P. sp. F3. After purification and identification of these antibiotic compounds, the RMEs were identified as analogs of the rhamnolipids produced by Pseudomonas aeruginosa, a biosurfactant with […]
Pranav Kolluri
It is increasingly being recognized that diabetic bone disease, associated with an increased risk of bone fractures, cannot be detected effectively using traditional detection methods for osteoporosis. This is because patients with Type 2 Diabetes (T2D), despite having normal or even high bone densities, are still prone to fractures. The Bone Quality Research Lab at UCSF has established that deficits in the cortical bone structure are associated with T2D and the increased fracture potential found in those with T2D. My research will further develop this finding by determining if T2D […]
Jennifer Lee
Understanding niche differentiation is fundamental for comprehending the complicated process of adaptive radiation, a process characterized by the rapid formation of many ecologically different species from a single ancestor. However, the way in which niche differentiation is achieved during the early stage of adaptive radiation is still highly debated among evolutionary biologists. On the one hand, through the process of character displacement, natural selection could facilitate differentiation and diversification between closely related species where they co-occur with no need for prior niche differentiation at the time of secondary contact. Alternatively, […]
Kenneth Loi
mRNA has proven to be a promising novel therapeutic class due to its programmability, low barriers to synthesis, and rapid translation into protein in vivo. mRNA as a platform technology has led to the development of broad applications such as vaccines, therapeutic protein replacement, in vivo genome editing, and in vivo cellular reprogramming. Despite growing interest in mRNAs therapeutic potential, it suffers from low delivery rates due to its instability and short half-life, thereby limiting its clinical adoption. mRNA transcripts are vulnerable to various degradation mechanisms in the cell, as […]