Undergraduate Research & Scholarships

Swetha Palaniappan

Investigating the role of SYNE1 Giant in Atrial Cardiomyopathy

As the heart moves through contraction and relaxation cycles, cardiomyocytes endure tremendous mechanical stress. This project aims to understand how cardiomyocyte nuclei integrate these mechanical stresses to maintain homeostasis. Specifically, we are studying the role of SYNE1-Giant, which is a component of the LINC-complex that tethers the nucleus to the cytoskeleton, in the atrial myocardium. As epidemiologic data has linked mutations in SYNE1-Giant with atrial cardiomyopathy and cardiac conduction disease, we hope to develop an understanding of the molecular mechanisms which link SYNE1-Giant to these pathologies.

 

Message To Sponsor

Thank you so much for supporting my research endeavors this summer. As an out-of-state student, your generous contribution has allowed me to spend my summer in the Bay Area and continue to advance my research skills.
Major: Molecular & Cell Biology
Mentor: Vasanth Vedantham, UCSF
Sponsor: Holmes Olson Fund
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