Development of a genetically encoded tool for manipulation of metabolism
Diet and exercise induce changes in metabolism that are associated with longer lifespan and decreased mortality from age-associated diseases. However, the specific bioenergetic changes within cells that cause these beneficial effects are not known. Professor Titov and I have been working on developing a genetically encoded tool to manipulate metabolism (GEMM), allowing us to control a single bioenergetic parameter in living cells. I plan to test the activity of this GEMM in different compartments of the cell using various experiments.