Stephanie Tjho
Circadian rhythms, generated in the suprachiasmatic nucleus (SCN) in the brain, are found in a wide range of organisms, and play an important role in the generation and maintenance of many biological processes. Chronic disruption of the circadian rhythm, as seen in flight attendants and other shift workers, has been found to be correlated with increased cancer rates. My project will examine the impact of jetlag on immune function, and use cell sorting methods to examine whether there is a change in the amount produced or time of production of […]
Paolo Solano Manzanillo
Baber Khan
Frontotemporal Dementia patients suffer behavioral disturbances which mimic primary psychiatric illnesses such as bipolar disorder or schizophrenia. Unfortunately, awareness of this neurodegenerative disease is limited in the psychiatric world and often demented patients are misdiagnosed. The Memory and Aging Center (MAC) at the University of California San Francisco conducts one of the largest investigations into the frontal variant dementias in the nation. I plan to systematically review 450 patients research charts at the MAC in order to precisely quantify the rate of psychiatric misdiagnosis for each of the dementia subtypes. […]
Spencer Diamond
Cell-cell fusion is a highly regulated event that is fundamental to the development of most eukaryotic organisms. However, despite its fundamental roll, the mechanisms of cell-cell fusion in most systems are not very well understood. Using the orange bread mold Neurospora crassa, I plan to study one of its integral membrane proteins known as prm-1. Prm-1 is implicated in the function of the cell-cell fusion pathway for N. crassa. Clues as to the exact function of the prm-1 protein will be gained by significant phenotypic analysis of growth and sexual […]
Jane O
Because any given cell carries an overwhelming excess of genetic information, they need a way to selectively pinpoint what they need, when they need it. Silencing entire regions of the genome via chromatin modifications is one method that eukaryotes have developed to great effect. The four SIR (Silent Information Regulator) genes are absolutely critical to silencing in yeast. Wild-type Sir3 typically requires Sir2s deacetylation activity, and not just the deacetylation itself, in a mechanism that is still unclear. I will use sequencing and protein structural analysis to study PCR generated […]
Toral Trivedi
It has been discovered that Curly, the early developmental mutation in Xenopus tropicalis, a frog model for human biology, leads to an abnormal number of Mitotic cells during the cell cycle. The mutant phenotype is possibly due to the abnormal expression of cell cycle factors. Mapping the location allows us to study these factors, creating a greater understanding of cancer. My project focuses on using primers to map the Curly mutation by using a combination of two methods. One involves natural mating between hybrid Curly carriers, and the other generates […]
Elliot Miles Asher Cohen
Brandon Endo
There are forms of the gecko species, Heteronotia binoei, that reproduce sexually that gave rise to forms that reproduce asexually through the process of parthenogenesis. Parthenogens have sections of duplicated genes in their mitochondrial genome while sexual forms do not. My project is to sequence and compare the mitochondrial genes of the sexual and parthenogenic forms to characterize their evolution since their divergence. I will also compare duplicated gene copies to one another within the parthenogenic individuals to characterize evolution of each gene since the duplication event. Gene duplication and […]
Eduardo Habitan Europa
My project investigates the nature of basic human economic principles with special focus on the scarcity bias – the tendency to select objects in greater scarcity. A recent study observed children were more likely to choose an object from the less abundant of two sets (Markson, personal communication). Before explaining this behavior, I am seeking factors that could confound this bias. I plan to test children and adults and see if visual information is required for exhibiting this behavior. Subjects will have the option of choosing an object after providing […]
Seita Onishi
My project is to design, test and construct an electronic amplifier customized for data-taking in low temperature experiments (liquid helium cooled) at the Quantum Nanoelectronics Laboratory. Electrical signals from experiment samples are too weak to be measured directly, so this amplifier will make the signals stronger. For the transistor, the essential part of the amplifier, I will use a commercial Silicon-Germanium transistor, which is known for its low cost. Using computer simulations and testing of the amplifier characteristics, amplifiers for various experiments in the lab demanding different frequency ranges can […]