Hongsik Park
A detailed mechanism of this so-called “feature detection” has been recently studied in humans; however, this mechanism has not been investigated in any animal model yet (Neri and Heeger 2002). Due to the general belief that rodents have very poor vision, scientists have paid little attention to them on the topic of visual perception. However, studies in the last 10 years have actually shown that the rodent visual systems present properties similar to those of other mammals such as cats and monkeys. Therefore, I believe rodents could be used as […]
Joo Yeon (Jenny) Ryu
9-cis-retinoic acid (9cRA) is one of the many derivatives of vitamin A. Although vitamin A derivatives are most known for their involvement in sight, they are involved in many physiological process such as the immune response, the development of many organs, and the maintenance of normal internal conditions like blood glucose. Normally, glucose levels are closely regulated by hormones of the pancreas such as insulin and glucagons. However in the case of diabetes, this tight regulation collapses. 9cRA has shown potential in correcting the hormonal imbalance characteristic of diabetes. How […]
Kenny Hoo Chow
Zachary Westrick
My experiment examines two possible models of how the brain determines which arm to use during reaching movements. Under the non-competitive model, the motor areas in each hemisphere formulate a plan and race until one has reached some threshold level of activation for movement, while the competitive model has the two hemispheres race while sending inhibitory signals to each other. I’ll be giving subjects a simple reaching task in which they must respond to cues on a screen, but occasionally withhold their movement in response to a later stop cue. […]
Eduardo Habitan Europa
My project investigates the nature of basic human economic principles with special focus on the scarcity bias – the tendency to select objects in greater scarcity. A recent study observed children were more likely to choose an object from the less abundant of two sets (Markson, personal communication). Before explaining this behavior, I am seeking factors that could confound this bias. I plan to test children and adults and see if visual information is required for exhibiting this behavior. Subjects will have the option of choosing an object after providing […]
Yannan Shen
Type II topoisomerases are enzymes that can change the topology of circular DNA molecules. These enzymes are essential to every living organism, which makes them good targets for anti-cancer and anti-bacterial drugs. DNA topology assays are used to determine the efficiency of topoisomerase inhibitors in drug design. In my research, I focus on the unknotting probability of knots by type II topoisomerases. In our previous study, our group built a mathematical model in simple cubic lattice to simulate how random strand passages generate the knotting distribution. We intended to use […]
Lauren Zerbib
The basis of sexual reproduction is a perennial topic of interest in evolutionary biology. The rotifer, Brachionus Calyciflorus, is an interesting system to compare sexual and asexual reproduction because it is cyclically parthenogenetic, meaning it alternates between generations produced sexually and asexually. By understanding the mechanisms controlling the timing of sexual reproduction in such organisms, we can better understand how natural selection determines the balance between asexual and sexual reproduction. In this study I look at the contributions of three related factors in determining the proportion of sexually reproducing daughters […]
Jane Yu
We are studying the role that a gene called KST245 plays in joint formation in mice. Currently, little is known about the regulation of joint development in the field of skeletal biology. However, through our research we hope to advance the field and share information that may be important in treating poorly understood joint diseases, such as arthritis. Mice that lack the functional KST245 gene (KST245 mutants) show irregular cartilage growth and misplaced joints. By examining the differences between the KST245 mutants and unaltered mice, we hope to understand the […]
Maansi Shah
DivL is an essential protein in Caulobacter crescentus that acts upstream of the master cell-cycle regulator, CtrA. Sequence analysis shows DivL to be homologous to histidine protein kinases, however, it has a tyrosine at its active site rather than a histidine. DivL is an essential protein but a mutant form of the protein, in which autophosphorylation is prevented by the substitution of phenylalanine for the tyrosine at the phosphorylation site, is still capable of supporting viability. Thus, DivL activates CtrA by a mechanism other than phosphorylation. The goal of my […]
Kamelia Ghazi
Curcumin (CUR), the active chemical of the Asian spice tumeric, has a strong anti-oxidant, anti-inflammatory effect in preventing neurodegenerative diseases like Alzheimers (AD), as well as an anti-proliferative effect on cancerous cells. Based on broad ranges of scientific literature on this topic, CUR has correlated with dramatic reduction in acetylation of histone. However, the precise mechanism by which curcumin achieves hypoacetylation and therefore represses the transcription of cancerous cells, is poorly understood. In this experiment, I will culture C6 rat glioma cells and through using immunostaining and protein assay, I […]