Sarah Soliman L&S Sciences
Probing the Necessity of Intestinal Stem Cells for Renewal of the Adult Drosophila Midgut
In adult animals, many tissues undergo continuous renewal, a process in which older cells die and are replaced by newly born cells. These new cells are generated by the proliferation of tissue stem cells, which divide continuously throughout the animal’s lifetime. The process of tissue self-renewal has long been thought essential for the maintenance of tissue structure and function; however, this presumption has never been explicitly examined. In my SURF project, I will explore the necessity of tissue renewal using the Drosophila epithelial midgut as a model system. Specifically, my research entails the genetic elimination of Drosophila intestinal stem cells and determining the effects of stem cell loss on the structure and function of the midgut.