Sushil Bohara Sciences
Mapping the Spatial Pattern of Response to ALIC DBS Using fMRI
Obsessive-Compulsive Disorder (OCD) is a common psychiatric disorder characterized by intrusive anxiety-provoking thoughts and repetitive behaviors. Deep brain stimulation (DBS), an implantable neuromodulation therapy that can effectively modulate neural circuits in the brain using electrical stimulation, has emerged as an approach to treat severe cases of OCD. To address the current need for reliable biomarkers of OCD symptom response to DBS to inform the optimal brain targets for OCD patients, Sushil will evaluate functional MRI data acquired simultaneously to DBS in a cohort of patients with medication-refractory OCD to comprehensively map out the brain’s functional response to DBS at different therapeutic settings. Sushil will investigate the impact of DBS on the brain and uncover basic circuit principles underlying OCD.