Seung Won Lee Sciences
Genetic Modulation of Two Phosphatases, Ptpn6 and Ptpn22, to Examine their Role in NK Cell Desensitization
Natural killer (NK) cells play an important role in the innate immune system in eliminating viruses and tumors. Unfortunately in environments lacking class I major histocompatibility complex (MHC-I) proteins, as is the case in 40-90% of human tumors, the NK cells can become desensitized and unresponsive. In her project, Seungwon will modify the expression of two phosphatases, Ptpn6 and Ptpn 22, that have been found to be expressed at higher levels in anergic NK cells to study the molecular mechanisms of NK cell desensitization. Findings have the potential to guide NK cell cellular therapy.