Swetha Palaniappan
Investigating the role of SYNE1 Giant in Atrial Cardiomyopathy
As the heart moves through contraction and relaxation cycles, cardiomyocytes endure tremendous mechanical stress. This project aims to understand how cardiomyocyte nuclei integrate these mechanical stresses to maintain homeostasis. Specifically, we are studying the role of SYNE1-Giant, which is a component of the LINC-complex that tethers the nucleus to the cytoskeleton, in the atrial myocardium. As epidemiologic data has linked mutations in SYNE1-Giant with atrial cardiomyopathy and cardiac conduction disease, we hope to develop an understanding of the molecular mechanisms which link SYNE1-Giant to these pathologies.
Message To Sponsor
Thank you so much for generous contribution. Being able to be in the lab is one of my favorite parts of the week. This summer, I was able to go full-time for a few weeks which I greatly appreciated. As an out of state student, my original plan was to work closer to home, however this stipend gave me the opportunity to stay in the bay. Through my summer experience, I was able to learn new skills such as the basics of stem cell culture, and mouse work and I'm excited for the school year to begin so I can get back to it! Thank you again for this opportunity.
Major: Molecular & Cell Biology
Mentor: Vasanth Vedantham, UCSF
Sponsor: Holmes Olson Fund