Emily Zhao
Understanding the genetic basis of organ regeneration remains a central challenge in the field of developmental biology. Teeth are a classic model for organogenesis, since many homologous ectodermal organs (e.g., teeth and hair) follow similar patterns of development and regeneration. Threespine stickleback fish are a powerful model organism for studying tooth regeneration in vertebrates because they possess the ancestral dental phenotype of polyphyodonty, in which teeth are continuously replaced throughout adult life. Past research has shown that Foxc1 regulates Bmp6, a gene important for viability, growth, and tooth patterning […]
Xiaozhou Zhang
The perception of a stimulus is strongly influenced by the background surrounding it. In mammals, this figure-ground perception to identify stimuli from the environment is crucial for survival, such as detecting predators. My project aims to explore the neural mechanisms behind figure-ground perception, especially focusing on the role of vasointestinal peptide positive (VIP) and somatostatin (SOM) interneurons in the primary visual cortex (V1). To explore the mechanism, I will first develop a novel mice behavioral task that can accurately quantify figure-ground modulation. Then, I will use optogenetics to activate or […]
Amy Wu
This research project examines the rich history and future of midwives of color in the Bay Area through the novel implementation of Science, Technology and Society (STS) frameworks. By defining the midwifery model of care conceived by Bay Area midwives of color as a complex sociotechnical system, the process by which midwives of color have created their models of care can be explored at the intersection of the nation’s capitalistic healthcare system, historic attempts to destroy the knowledge produced by grand midwives in the antebellum period and broader African diaspora, […]
Divij Sharma
Strong gravitational lenses (deflection of light into multiple images by gravitational field of mass concentrations like galaxies) have been used as cosmological probes. These techniques involve ratios of distances between the observers, lens, and source. DSPL systems involve two sources lensed by the same foreground mass concentration. They provide a unique cosmological geometric probe through distance ratios involving the source and lens. Cosmic acceleration has been described using a form of energy called dark energy. Previous work by my advisor has shown that the DSPL key distance ratio is nearly […]
Alexander Richardson
Geometric flows, such as the Ricci flow, Yang-Mills flow, and harmonic map flow, are natural ways to smooth out geometric objects (metric, connection and maps, respectively). In this research project, we will explore the idea of using geometric flows to develop new analytic tools for studying geometric objects. A possible goal of this project is to use geometric flows to solve problems in dispersive PDEs that involve geometric objects.
Tannya Tang
In arthropods and vertebrates, Hox genes determine how an organism develops along the axis running from its head to its tail. Little is known of Hox function outside of these standard animal models, but studies in annelids (segmented worms) suggest that Hox genes not only play a conserved role in embryonic patterning, but are also deployed in ways specific to annelids. For example, hox3 is expressed around the posterior growth zone (PGZ), from which all new segments arise. I hypothesize that hox3 is a stem cell marker in annelids that […]
Alexander Toller
Suppose that we have a (finite or infinite) series of independent, identically distributed real-valued random variables (increments of time). From this series, we can form a random walk. We can consider the partial sums of this series and analyze the average value of the walk the partial sum divided by the number of increments up to that point at each of its time increments. This project is focused on studying the distribution of the maximum average value of a random walk through a variety of computational algorithms. While there already […]
Jiayi Tan
People with high level of nearsightedness will have a 5- to 10-fold chance of developing glaucoma, cataract, and sight-threatening diseases such as retinal detachment later in life. Atropine eye drop is one of the most effective therapies for nearsightedness control. I will conduct a small-scaled randomized controlled trial to understand the impact of eye color on the effectiveness of atropine eye drop. Many studies on atropine have focused on Asian populations, and few studies have compared the effect of atropine between Asians and Europeans, who tend to have much lighter […]
Tiffany Tian
Up to half of Wilsons disease patients suffer from sleep disorders, including poor sleep quality, REM behavioral disorders (RBD), and cataplexy. However, the neural basis of these symptoms is poorly understood. My project this summer is to determine whether the ATP7B-/- knockout mouse is a good model system for studying the sleep disorders manifested in Wilsons disease, especially in the context of neural pathways involving copper homeostasis. Using automated sleep scoring methods, we will quantify sleep signatures in ATP7B-/- knockout and wildtype control mice. The brain copper changes in recorded […]
Britney Weng
In humans, Positive Transcription Elongation Factor b (P-TEFb) is an RNA Polymerase II regulator crucial for proper gene expression. To execute its regulatory function, P-TEFb itself is precisely regulated via reversible interactions with an snRNP complex. Using biochemical techniques, past studies have confirmed LARP7, HEXIM1, and BRD4 to be protein partners of P-TEFb. My project aims to study the dynamic regulatory role of known protein partners LARP7, HEXIM1, and BRD4 in P-TEFb regulation. I will apply a new technique called proximity-assisted photoactivation (PAPA) to single particle tracking (SPT) and […]