YeeAnn Chen L&S Sciences
Characterizing the Tumor Suppressive Functions of MIR-449 miRNAs in the E-myc B Cell Lymphoma Mouse Model
Cancer is a potent disease that occurs when cells acquire certain mutations that cause uncontrollable cell growth. MicroRNAs (miRNAs) are small non-coding RNAs that have been associated in cancer development. In our research, we specifically study the tumor suppressive effects of miRNAs on B cell lymphoma, a type of blood cancer in the lymph nodes. We have determined that the deletion of mir-34a or mir-34bc (tumor suppressive miRNAs) accelerate lyphomagenesis. More recently, it has been shown that there is a homologous cluster of miRNAs, the mir-449 family, suggesting similar functions. While the ultimate goal is to understand how these miRNA clusters interact and collectively act in a tumor suppressive role, I aim to understand the effects of losing the mir-449 cluster alone on lymphomagensis. I propose to determine the extent of acceleration of lymphomagenesis due to the loss of mir-449, and whether this acceleration is through proliferation or cell death.