Sona Asatryan Rose Hills
Can a Nox2 Inhibitor Attenuate Post-Stroke Hyperglycemia?
Every 40 seconds, someone in the US experiences a stroke. Ischemic stroke triggers a stress response in the body, inducing hyperglycemia which exacerbates outcomes following stroke.
One mechanism by which hyperglycemia worsens stroke symptoms is by fueling NADPH oxidase-2 (NOX2) activity, producing superoxide and increasing cellular damage through oxidative stress. Inhibiting NOX2 activity may serve as a potential treatment.
While hyperglycemia after stroke is common, its treatment with insulin is not a viable option due to the risk of developing hypoglycemia. Therefore, a thorough investigation of hyperglycemia after stroke is clinically relevant to develop treatment plans to combat this common condition.
My proposed project will investigate the effects of NOX2 inhibition in a murine model of ischemic stroke with induced hyperglycemia. I hypothesize that a NOX2 inhibitor will attenuate the deleterious effects of hyperglycemia after stroke. I hope my project will reveal information of the possibility of NOX2 inhibition as a treatment plan for stroke patients experiencing hyperglycemia.
Message To Sponsor
I would like to sincerely thank my donor for funding my summer research project. I am so grateful for this opportunity to hone my skills and grow as a scientist. Thanks to your contributions, I have been able to participate in the advancement of neuroscience research!