Shuangyue Li L&S Biological Sciences
Delineate the role of Notch4 Receptor in Arterial Outward Remodeling
Embedded within the intricate tapestry of cardiovascular diseases lies the cornerstone of vascular health. Arteries are vital conduits responsible for delivering oxygenated blood away from the heart and to the body. It is known that Notch signaling is crucial for the mature development of vascular identity and network, and previous research on loss-of-function Notch receptors demonstrates impaired artery growth and remodeling. Previous research at the Wang lab has shown that pan-endothelial constitutive expression of Notch4 causes enlarged arteries, but it cannot exclude the role of hemodynamic perturbations. My summer project will focus on investigating if activated Notch is sufficient to promote flow-induced arterial outward remodeling. I will do so by genetically manipulating Notch mice and selectively activating Notch4 in arterial endothelial cells using BMX. Results will contribute to unveiling the molecular underlying of sprouting angiogenesis and targets of vascular diseases.
Message To Sponsor
I would like to express my honor of being selected as a SURF fellow and my sincere gratitude for your gracious funding of my summer research. I am passionate about contributing to the field of vascular health and hope to pursue a related medical field in the future. This opportunity will facilitate my growth as a scientific scholar and as a critical, independent thinker.