Sanjana Shankar L&S Biological Sciences
The Effect of Psychedelics and Sex Differences on Neurodegeneration
Alzheimer’s Disease (AD) is a debilitating disorder that can lead to difficulty thinking, while also disrupting an individual’s ability to carry out bodily functions. With no known cure, those diagnosed with Alzheimer’s live an average of 4-8 years after detection of the disease.
A mutation in a gene known as APOE4 has been implicated as a high risk factor for AD. Specifically, this genotype leads to higher risk of AD in women who are carriers of the gene. However, the mechanisms involved in differences between male and female patients is unclear, and could affect treatment. The foundation of this research project is to understand the sex-dependent biological mechanisms of the APOE4 variant which could be key to developing successful pharmacological interventions.
Ultimately, this study aims to 1. broaden the current understanding of differing biological mechanisms between male and female brain degeneration and 2. aid in successful development of sex-specific, targeted therapeutics.
Message To Sponsor
Ever since I began my research journey in 2023, I have dreamed of taking on my own project and presenting my findings to an audience. Being able to lead my own project in the Kaufer Lab at UC Berkeley has been one of the most rewarding experiences of my life. I want to sincerely thank you for your support in our research, which has the potential to benefit millions impacted by the devastating effects of Alzheimer's Disease. None of my astounding progress and growth as a student researcher this summer would have been possible without your support. I will continue to hold this gratitude close as I continue my journey in contributing to and learning from the field of psychedelic research.