Nicole Goldberg-Boltz L&S Sciences
Investigating Inhibitory Effects of the Pre-SMA in a Response Inhibition Paradigm
We are frequently required to halt or alter ongoing actions when an unexpected event is presented. For example, when we start crossing the street and we see an unanticipated car, we have to suddenly halt. In neuroscience, this sudden suppression of movement is referred to as response-inhibition. Response-inhibition deficits have been linked to disorders such as ADHD, obsessive-compulsive disorder, and substance use disorders. However, the exact neural pathways engaged in response inhibition are undefined, which I am interested in uncovering. For my project, I will focus on three proposed areas of the brain involved in response-inhibition known as the pre-supplementary motor area, pre-motor and primary motor cortex. Specifically, Im interested in uncovering key information regarding the role of the pre-supplementary motor area in the stop-inhibition network. Understanding of this network may provide insight into diseases with impaired response-inhibition, and potentially provide a basis for the development of therapies.