Nadir Bilici Rose Hills
Characterizing Dopamine D1R and D2R expressing neurons in the medial prefrontal cortex
Many years of research have established dopamine as a key neuromodulator required for learning and adapting behavioral responses to a changing environment. Dopamine actions are mediated by two classes of receptors, with largely antagonistic effects: the D1 group mainly leads to excitation-like effects in neurons, while the D2 group has inhibition-like effects. Particularly, the medial prefrontal cortex contains neurons expressing both D1 and D2 receptors, which have been implicated in a large number of normal and pathological behaviors. Although recent research links dopamine receptor D1 expressing neurons to working memory in the PFC, most studies do not explain how normal dopamine release, acting through both D1 and D2 receptors is able to produce a coherent behavioral effect. How does dopaminergic neuromodulation in the medial prefrontal cortex lead to plasticity and learning? The goal of my project is to characterize the role of dopamine receptor D1 and D2 expressing neurons in the medial prefrontal cortex.