Lucy Jiwu SURF SMART
Improving Cognition in Alzheimer's Disease through Light Stimulation
In Alzheimer’s disease (AD), there is a clear relationship between reduced cognitive ability, asynchronous brain wave oscillations, and neuroinflammation. Microglia, the immune cells of the central nervous system, no longer efficiently target and clear amyloid-beta, leading to an accumulation of plaques that disrupt neuronal communication. This summer, my mentor and I are interested in manipulating oscillatory activity at the gamma wave frequency associated with optimal cognition (40Hz), as a target for therapeutic intervention. We will test a new invisible light-flicker technology on a mouse model of AD that pilot data suggests will synchronize brain wave activity and neuronal firing to induce healthy neuroimmune system functioning. We predict that with 40Hz stimulation, microglia will better function in clearing amyloid-beta plaque accumulation and improve cognition. By employing quantitative PCR, we will isolate microglia and characterize their cytokine profiles to increase our understanding of how non-invasive sensory stimuli can induce large-scale changes in neurophysiology. This research merges science and technology and will expand our knowledge of AD and shed light on potential approaches for further research in the field.