Kamelia Ghazi L&S Sciences
Investigation of the Genetic Mechanism by which Curcumin Achieves the Hypoacetylation of Histone
Curcumin (CUR), the active chemical of the Asian spice tumeric, has a strong anti-oxidant, anti-inflammatory effect in preventing neurodegenerative diseases like Alzheimers (AD), as well as an anti-proliferative effect on cancerous cells. Based on broad ranges of scientific literature on this topic, CUR has correlated with dramatic reduction in acetylation of histone. However, the precise mechanism by which curcumin achieves hypoacetylation and therefore represses the transcription of cancerous cells, is poorly understood. In this experiment, I will culture C6 rat glioma cells and through using immunostaining and protein assay, I will quantitatively monitor the proliferation and differentiation of neuroglial cells with different doses of CUR. Hopefully, this research will provide further explanations of CURs preventive-therapeutic role in wide ranges of neurodegenerative diseases.