Joy Hsu L&S Sciences
Induction of PD-1 expression on NK cells by Tregs
Several lines of evidence support a role for Natural Killer (NK) cells in the immune response to tumors. We recently found that PD-1, a receptor capable of powerfully suppressing the functions of T cells, is expressed by NK cells. However, the cellular networks responsible for PD-1 expression on NK cells are not known. Here, we propose to study the contribution of Regulatory T cells (Tregs) in inducing PD-1 expression on NK cells, by using both an ex vivo and in vivo approach. The proposed research plan will provide important knowledge on the cross-talk between NK cells and Tregs in the context of an immune response to a tumor.