Jifang Xiao Rose Hills
Applications of Human Pluripotent Stem Cells (hPSC) Derived Dopaminergic (DA) Neurons in Treating Parkinson's Disease in Rodents
Parkinsons Disease (PD) affects approximately seven to ten million individuals worldwide and is the result of the progressive degeneration of neurons within the brain. The neurological disease is commonly associated with numerous debilitating motor and non-motor features. Recently, transplantation of fetal midbrain tissues to the SN has been investigated to treat PD in humans. However, this therapy is limited by the fetal tissue availability, low reproducibility, and ethical issues. A solution for these limitations is to engineer DA neurons from hPSCs. We recently developed and reported a simple, defined, efficient, scalable, and good manufacturing practice (GMP) compatible 3-dimensional culture system for hPSC expansion and differentiation. Using the previously reported system, we will aim to address questions pertaining to the safety, integration, and efficacy of a PD treatment using hPSC-derived DA neurons in a rodent model. We hope that our findings will help push the field of regenerative medicine closer to the cure for Parkinsons.