Han Xiao L&S Biological Sciences
Role of Ubiquitin-Proteasome System in Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) is a blood cancer caused by the failure
to produce mature blood cells, with a five-year survival rate below 30%.
Understanding the molecular mechanisms of AML is essential for
developing effective therapies. Recent studies show that AML cells rely
on the mitochondrial electron transport chain (ETC), and ETC activity
enhances overall cancer cell survival. Our lab has previously discovered
several E3 ubiquitin ligases that directly sense and regulate
mitochondrial import and activity. My project focuses on deciphering the
specific binding sites that these ligases use to recognize novel key
mitochondria-related substrates. By uncovering how this degradation
process works, we hope to identify new strategies to block cancer-
specific energy pathways in AML.
Message To Sponsor
I greatly appreciate the opportunity provided by SURF, which will allow me to have an immersive research experience throughout the summer. “With the power of science, one day, the so-called terminal diseases will become curable,” I have deep faith in this statement. The SURF fellowship would support this vision by recognizing my potential as an emerging scientist and encouraging me to continue pursuing impactful research.