Han Amy Li L&S Sciences
Dynamic Regulation of the Circadian Control of Ovulation in the AVPV of the Hypothalamus
This research attempts to determine how the circadian system controls the timing of ovulation, a requirement for successful reproduction. Initiation of ovulation requires a signal from the brain’s master clock, the suprachiasmatic nucleus (SCN). This signal’s necessity in most mammals, including humans, is apparent as disruptions in circadian rhythms lead to reproductive deficits. Currently, the neural pathways and neurochemical mechanisms by which the SCN triggers ovulation remain uncharacterized. Previous work indicates daily rhythms of GABA and kisspeptin, neurotransmitters that inhibit and stimulate ovulation, respectively, are crucial for reproductive maintenance. We will explore the cellular and molecular pathways associated with the coordination of GABA and kisspeptin expression, as well as their roles in the timing of ovulation, using Syrian hamsters, a well-studied animal model of ovulation. This work will contribute to gaining more insight into and finding new treatments for current problems in health fields such as infertility and maternal-fetal health.