Hai Le L&S Sciences
DNA Damage Checkpoint Activation in Heterochromatin
It is essential that the cell preserves the integrity of its DNA by initiating a proper response when there is damage to its genome. As a fellow of the Summer Undergraduate Research Fellowships, I am utilizing this summer and the senior academic year to study the DNA repair pathway in heterochromatin. Using Drosophila melanogaster as a model system, I propose to fluorescently tag different DNA repair proteins and conduct experiments to understand the kinetics of these proteins following DNA damage induced by X-ray treatment. This research is promising: knowledge of how cells repair DNA damage in heterochromatin can contribute to a better understanding, and therefore, potential treatments of diseases associated with damage to our genome (e.g., cancers).