Germaine Mendez Rose Hills
An Insight into Unlocking the Regenerative Potential of Cardiomyocytes
Despite the apparent limitations in the regenerative capacity observed in higher vertebrates, regeneration was observed to be induced in non-regenerative animals, indicating that the potential for regeneration is in fact present. A recent regenerative study demonstrated that administration of amino acids (L-leucine and L-Glutamine) and insulin/sugar, induced a regenerative response in Drosophila and mice, species known to have limited regenerative potential. The results of this study demonstrate a remarkable conserved effect of nutrient supplementation on the activation of regeneration between species with a high degree of evolutionary divergence. This suggests the existence of an underlying energetic parameter driving tissue regeneration across species, which implies that these findings may be replicated in specific tissue types, such as in cardiac tissue composed of cardiomyocytes, which are known for their lack of regenerative capability. By identifying and targeting the potential energetic parameters that facilitate tissue regeneration, I hypothesize that the administration of amino acids and other nutritional components may promote cardiac regeneration in both Drosophila and mice. If the regenerative effect can be harnessed and applied to damaged cardiac tissue, it could offer promising therapeutic interventions for heart disease by promoting tissue regeneration.