Davina Dou Rose Hills
Spatiotemporally Mapping the CRISPR-CasX Binding and Repair of DNA
As a fellow, I will be working to develop a live-cell imaging platform to understand the mechanisms of the CRISPR-CasX endonuclease and its potential to be harnessed for gene-editing. More specifically, I will be looking at the length of the protein’s DNA binding and its rate of repair. My findings will provide a clearer understanding of CRISPR mechanisms in cells, and ultimately, how we could apply these interactions to treat human diseases in a timely manner.