Gabriel Perko-Engel
Largely unchanged for centuries, origami in the last hundred years has exploded with innovation! Beginning with the works of Akira Yoshizawa and his introduction of the first technical system for notating folds, paperfolding has transformed from a simple craft to a highly developed field of mathematics, engineering, and artistry. Yet, even as groundbreaking work has been done to determine what objects can be folded and how, fundamental questions remain about the dynamics of even the simplest moving models such as the traditional flapping bird. Building on the existing idealized work […]
Albert Kim
It is not yet known what causes autism spectrum disorder (ASD) on a molecular level, but recently, 65 ASD risk genes have been identified by a lab at UCSF. Albert is focusing on one of these genes, called Neurexin 1. He will be using CRISPR/Cas9 genome editing to knock out Nrxn1 in Xenopus tropicalis frogs and observing the phenotypic effects, such as increases and reductions in cell proliferation and differentiation as well as changes in regulation of other neural genes. Alberts goal is to illuminate the roles of this gene […]
Metta Nicholson
Wetlands, known for their potential to sequester carbon dioxide, also contribute to a substantial proportion of global methane emissions. Currently, there is a large effort to restore wetlands in the Bay Area in order to create carbon sinks to help combat the effects of climate change. However, it is essential that wetland managers and restoration scientists understand what factors influence the release of methane from wetland soils, since the release of methane offsets the uptake of carbon dioxide in these ecosystems. To contribute to the refinement of these management practices, […]
Maritza Cárdenas
Dengue virus (DENV) is a mosquito-borne virus with four distinct serotypes. Primary infection by any of the four serotypes may result in dengue fever or, in severe cases, progress to dengue hemorrhagic fever/dengue shock syndrome. Recent studies have challenged dogma in the dengue field by finding that serotype-cross-reactive neutralizing antibody titers in serum of children in a cohort study in Nicaragua increased marginally in the time between primary and secondary DENV infection rather than decreasing over time, implying re-exposure to DENV. Maritza will use a novel method the Quad-color Fluorospotto […]
Christopher McCarron
Soils derived from serpentine rock host a unique flora while being distributed throughout California in scattered outcrops. Their insularity makes them ideal for examining the evolution and divergence of species restricted to them, such as the leather oak (Quercus durata var. durata). Chris McCarron’s honors thesis will use reduced genome DNA sequencing for 310 samples from 31 separate populations throughout Q. duratas range. Results will determine the levels and depths of divergence among populations, spatial patterns of differentiation, their timing of isolation, and whether there was a single evolutionary event, […]
Geun Ho Ahn
Strain engineering is a ubiquitous technique utilized in the semiconductor industry to modulate and engineer the properties of semiconducting electronic materials. Various processes such as advanced high performance transistors, solid-state lasers, and integrated circuits adopt strain engineering to further optimize their performance. Simultaneously, two dimensional transition metal dichacogenides (TMDCs) have demonstrated their great potentials as the next optoelectronics and extremely scaled electronics; they can be scaled down to the atomic limit to be used for electronics. However, to date the merits of strain engineering have not been sufficiently employed nor […]
Zoe Hsiao
Human Cytomegalovirus (HCMV) is one of eight pathogenic herpesviruses known to infect humans. HCMV can be asymptomatic in those with sufficient immune systems, but lead to serious or fatal disease in immunodeficient persons. Because current medications to treat HCMV have a poor safety profile and risk the potential to select for drug resistance, vaccine development remains a top priority. The goal of this project is to better understand how a component of the human immune system, complement Factor H (FH), responds to HCMV. Zoe will employ a yeast-two-hybrid screen using […]
Danny Lee
Adenosine triphosphate (ATP) is a high energy molecule considered the energy currency for all species. Our laboratory has discovered that bacteria release ATP into culture medium, a novel phenomenon (Mempin et al., 2013). However, it isnt yet understood why this occurs. We hypothesize that extracellular ATP is needed for the conversion of D-amino acids and their incorporation into the cell wall, allowing bacteria to survive changing environmental conditions. Danny will investigate the role of ATP in D-amino acid metabolism and cell wall remodeling by measuring ATP release of cultures supplemented […]
Xinyi Zhang
Parkinsons disease is the second-most common neurodegenerative disorder, which currently has no effective treatment. The development of treatments can benefit from better understandings of how the neurodegeneration propagates in the brain. The most crucial contributor to the propagation is believed to be the transmission between neurons of the pathological protein, -synuclein. To study the unresolved transmission mechanism, Xinyi proposes an RNA-Seq study on neuronal models to measure the transient responses of cells exposed to -syn over time. RNA-Sequencing is a powerful tool for unbiased investigation of the highly coordinated responses […]
Lucian DiPeso
Pyroptosis is a poorly understood mode of cell suicide, one that functions as an alarm bell for the bodys immune system in response to infection. Though beneficial when properly regulated, the rapid immune response triggered by pyroptosis can, itself, produce disease and dysfunction. Pyroptosis has been identified as a possible contributor to cardiovascular disease, inflammatory bowel disease, and some neurodegenerative disorders. Understanding pyroptosis, then, could lead to novel treatments for a variety of human diseases. Unfortunately, despite ten years of research, uncovering how it precisely works has proven to be […]