Robert Bellerose

Biofuels have received much attention lately as the need for a renewable and carbon-neutral source of energy becomes increasingly important. We have assembled a biosynthetic pathway in Escherichia coli that produces butanol, a second generation biofuel, in six overall steps. However, there is a significant bottleneck at crotonyl-CoA reductase (Ccr) in the pathway that limits butanol production, which may be attributed to the observation that Ccr suffers from low solubility. The overall goal of my project is to carry out directed evolution of Ccr and generate a library of mutants […]

Roxanne Rajaii

Cell responses are mediated by signal transduction pathways that involve protein and lipid kinase cascades. One of the two essential PtdIns 4-kinases in the budding yeast (S. cerevisiae), encoded by the PIK1 gene, localizes both to the Golgi and in the nucleus and has an essential function in both compartments. Pik1 in the Golgi functions in regulating secretion from the Golgi to the cell surface, but the processes that Pik1 helps regulate in the nucleus are not well understood. In an effort to understand the essential role of Pik1 in […]

Sarah Carlson

This summer I will be exploring the origins of Gay, Lesbian, Bisexual and Transgender community spaces in the Bay Area. I am exploring primary sources such as newsletters and organizational records as well as doing oral history interviews with people closely involved in these centers. My study will span from the early 1950s, when many of the first homophile organizations opened offices in San Francisco, to the early 1980s, when local groups opened community centers throughout the Bay Area. Through this research, I hope to better understand the community wide […]

Joo Yeon (Jenny) Ryu

9-cis-retinoic acid (9cRA) is one of the many derivatives of vitamin A. Although vitamin A derivatives are most known for their involvement in sight, they are involved in many physiological process such as the immune response, the development of many organs, and the maintenance of normal internal conditions like blood glucose. Normally, glucose levels are closely regulated by hormones of the pancreas such as insulin and glucagons. However in the case of diabetes, this tight regulation collapses. 9cRA has shown potential in correcting the hormonal imbalance characteristic of diabetes. How […]

Elizabeth Castle

My current research takes advantage of the empathic, approach-oriented facets of compassion to investigate the broader concept of prosociality. My SURF project explores the neural basis of prosocial emotion by examining individual differences in dispositional traits in context of both central (with functional brain imaging) and peripheral (with measurements of vagus nerve activity) nervous system response to compassion inducing stimuli. The ultimate goal of my research is to identify both the dispositional traits that influence compassion, and the physiological factors that support prosocial behavior, and study how impaired compassion can […]

Stephanie Tjho

Circadian rhythms, generated in the suprachiasmatic nucleus (SCN) in the brain, are found in a wide range of organisms, and play an important role in the generation and maintenance of many biological processes. Chronic disruption of the circadian rhythm, as seen in flight attendants and other shift workers, has been found to be correlated with increased cancer rates. My project will examine the impact of jetlag on immune function, and use cell sorting methods to examine whether there is a change in the amount produced or time of production of […]

Chen Chen

One of the most surprising conclusions to emerge from whole genome sequencing projects in the last decade is that all animals have roughly the same number of genes. Initially, this seems contradictory to the idea that higher organisms have more genes to account for higher levels of complexity. However, one potential explanation is alternative pre-mRNA splicing, through which different exon combinations are incorporated into mature transcripts, thereby increasing the number of proteins encoded by a limited number of genes. Although there have been extensive studies in vitro concerning the biochemical […]

Connie Wang

My research project is designed to tease apart the contribution of circadian irregularities on reproductive performance. Circadian rhythms are essential for the maintenance of ~24 hour cycles in behavior, physiology, and neural function required for normal health. In humans, chronic or acute loss of synchrony between the circadian clock in the brain and the environment through shift work, jet lag, poor sleep hygiene, etc., leads to numerous health problems. Of great concern, many studies show that disruptions in circadian function lead to infertility, spontaneous abortion, and low birth weight in […]

Karlyn DeSteno

All musical compositions borrow some material. It is not always easy for the law to draw the line between theft and inspiration. Recent changes in copyright law point to new systems of valuation of musical elements, both cultural and legal. This summer Ill be tracing these changes through a musical and legal analysis of music written for television and commercials, focusing on compositions which seek to copy elements of other, original works. Ill spend one month in Washington, D.C. using archives at the Library of Congress, and will also conduct […]

John Wang

Muscle fibers are lined with small, non-fiber cells that reside between fiber bundles. These cells are called satellite cells. They are muscle stem cells which repair muscle upon injury. Satellite cells are important for use in stem cell therapies as they can self-renew and maintain their numbers following transplantation. Pax7 is a protein that has previously been reported to be uniquely expressed in satellite cells. As such, it is often used to verify the identity of cells collected from whole muscle biopsies. My project aims to show that Pax7 is […]